Ingo Elfering talks a lot about opportunities. That's not surprising, considering he has built his career on developing transformative uses for IT. In 1987 he founded his own company, MedicalData Service, which developed software for the medical community. SmithKline Beecham bought Elfering's company in 1997 and hired him as part of the deal. A native of Germany, he came to the U.S. with his wife in 2000 when a merger created GlaxoSmithKline. Last November, Elfering became vice president of business transformation for the company's Core Business Services. He now holds dual American and German citizenship and was named one of Computerworld's 2010 Premier 100 IT Leaders.