Queensland Health CIO Paul Summergreene has been sacked, amid rigorous investigations into allegations he cashed-in up to $25,000 in false expenses.

The management change comes only six months after Summergreene joined the department after a lengthy tenure at the Queensland Department of Transport, where he oversaw a series of significant IT projects including the creation of the QLD smartcard drivers license.

Summergreene's actions are currently being investigated by the Crime and Misconduct Commission (CMC). A spokesperson for the Health department refused to disclose details pertaining to Summergreene's alleged misconduct.

Queensland Health Director General Michael Reid said in a written statement that the new acting CIO, Dr Richard Ashby, is well qualified for the job.

"To ensure this happens, the experience and knowledge of current clinical information systems should be reflected in the senior leadership of Queensland Health, hence the appointment of Dr Ashby," Reid said.

"Dr Ashby has had leadership roles in both emergency medicine and medical administration for many years in Queensland Health at both the Royal Brisbane and Women's Hospital and Princess Alexandra Hospitals, and nationally through the respective colleges.

"He has major interests and expertise in clinical and administrative information systems."

The press release issued by the department made no reference to Summergreene, describing the changeover only as a new appointment.